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https://www.nature.com/articles/d41586-021-02853-4researchers have shown that such ‘mix and match’ regimens are highly effective at preventing COVID-19 — roughly matching or even exceeding the performance of mRNA vaccines.
The high antibody levels and other strong immune responses elicited by mix-and-match regimens suggested they would offer good protection against disease. Still, “I was delighted to see that it’s as effective as one would expect,” says immunologist Martina Sester at Saarland University in Homburg, Germany. “This is really good news and this will certainly have influence on clinical practice.”
“These emerging effectiveness data support the use of these approved COVID-19 vaccines in either the standard or mixed schedules,” adds Matthew Snape, a vaccinologist at the University of Oxford, UK.